Endocrine Abstracts

Introduction: Hirata Syndrome (SH) is a rare cause of autoimmune hypoglycemia, characterized by elevated circulating insulin levels without concomitant increase in C-peptide, anti-insulin antibodies positivity and pancreas alterations absence in patients never exposed to exogenous insulin. It is also known as insulin autoimmune syndrome (IAS) and is a relatively rare cause of spontaneous hypoglycemia. The syndrome was first described in 1970 by Yukimasa Hirata in Japan, the co...

Background: Immune checkpoint inhibitors (ICIs) showed impressive results in several malignancies; however, a large spectrum of immune-related adverse events (IRAEs) may occur, including thyroid dysfunction (DYSTHYR). IRAEs seem to be associated with better cancer outcome; limited data suggested that thyroid toxicity could be a predictor of response to ICIs.Patients and methods: We retrospectively evaluated all patients who started treatment with the pro...

IntroductionPrimary hypothyroidism, which is one of the main endocrine complications of allogenic stem cells transplantation (allo-SCT), has been largely studied in children. Conversely, data on adults are still limited with a reported incidence widely ranging between 9 and 47%. Older age, multiple allo-SCT, chronic Graft vs Host Disease (cGVHD), prolonged immunosuppressive therapy and high-dose total body irradiation (TBI) have been indicated as potenti...